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Zelis Selects AWS as Preferred Cloud Provider to Accelerate AI-Powered Healthcare Financial Modernization

Zelis, a leading provider of healthcare technology solutions, has named Amazon Web Services its preferred cloud provider to accelerate its cloud-first strategy and deploy agentic and generative AI tools across payments, claims pricing, and member engagement.

The collaboration focuses on migrating workloads to AWS and building intelligent automation for payers, providers, and healthcare consumers.

Key Terms and Scope

  • AWS becomes Zelis’s preferred cloud provider.
  • Zelis will migrate workloads to AWS and expand use of AWS cloud-native services, advanced data architecture, and AI capabilities.
  • The partnership targets intelligent automation and workflow optimization in payments and claims pricing solutions.
  • Zelis will leverage Amazon Bedrock to build AI-powered capabilities supporting member engagement, along with agentic AI tools including Amazon Quick, Kiro, and AWS Transform to streamline operations.

Scale and Current Focus

Zelis serves more than 725 payers, including the top 5 national health plans, regional health plans, and third-party administrators (TPAs), plus millions of healthcare providers and consumers.

Its technology supports payers and providers at scale in a constantly evolving system, with the goal of improving how healthcare is priced, paid, and communicated so financial processes better support care.

Executive Quotes

“Our collaboration with AWS enables the next phase of growth at Zelis,” said Larry West, Chief Information and Data Officer at Zelis. “It enhances our ability to expand capabilities, respond quickly to client needs, and lead in an increasingly digital and AI-driven healthcare environment.”

“Healthcare organizations depend on trusted, resilient and highly scalable technology to support essential financial workflows,” said Allyson Fryhoff, managing director of global healthcare and life sciences at AWS. “We are proud to support Zelis as they build a strong cloud foundation that enables AI-powered innovation, all while maintaining the highest standards of security, reliability and compliance required for mission-critical healthcare financial operations.”

What This Means

The move marks a strategic shift for Zelis toward a cloud foundation explicitly designed to support long-term growth through AI-powered automation in highly regulated healthcare financial workflows. By combining AWS infrastructure with specific agentic tools (Bedrock for member engagement, Kiro and AWS Transform for operations), Zelis aims to deliver faster capability expansion and quicker response to client needs while upholding strict security, reliability, and compliance standards.

No fixed migration deadline was disclosed in the announcement, but the emphasis on “cloud-first strategy” and “AI-powered automation” signals an accelerated push beyond traditional infrastructure.

Actions to Take

Zelis engineering and product teams should prioritize migration roadmaps for core payments and claims pricing workloads, followed by rapid integration of Amazon Bedrock for member engagement features and Kiro/AWS Transform for internal workflow automation to deliver measurable speed gains for clients.

Payers and providers using Zelis solutions should prepare to evaluate upcoming platform updates for faster claims processing, improved pricing transparency, and new AI-driven member tools, and provide feedback on automation priorities during the transition.

Healthcare technology competitors should monitor Zelis’s post-migration performance on claims cycle times, pricing accuracy, and client responsiveness as a real-world test case for deploying agentic AI tools (particularly Kiro and AWS Transform) in compliance-heavy financial workflows.

AWS healthcare and life sciences teams can reference this deal when engaging other payer, provider, or healthcare fintech organizations seeking to modernize legacy financial systems with a focus on security, scalability, and agentic AI without compromising regulatory requirements.

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